diff --git a/toolkit/mozapps/extensions/content/extensions.js b/toolkit/mozapps/extensions/content/extensions.js
index 8d9c132e61..fc43922312 100644
--- a/toolkit/mozapps/extensions/content/extensions.js
+++ b/toolkit/mozapps/extensions/content/extensions.js
@@ -18,10 +18,12 @@ Cu.import("resource://gre/modules/addons/AddonRepository.jsm");
 XPCOMUtils.defineLazyModuleGetter(this, "PluralForm",
                                   "resource://gre/modules/PluralForm.jsm");
 
+#ifdef MOZ_DEVTOOLS
 XPCOMUtils.defineLazyGetter(this, "BrowserToolboxProcess", function () {
   return Cu.import("resource://devtools/client/framework/ToolboxProcess.jsm", {}).
          BrowserToolboxProcess;
 });
+#endif
 
 const PREF_DISCOVERURL = "extensions.webservice.discoverURL";
 const PREF_DISCOVER_ENABLED = "extensions.getAddons.showPane";
@@ -1002,6 +1004,7 @@ var gViewController = {
       }
     },
 
+#ifdef MOZ_DEVTOOLS
     cmd_debugItem: {
       doCommand: function cmd_debugItem_doCommand(aAddon) {
         BrowserToolboxProcess.init({ addonID: aAddon.id });
@@ -1015,6 +1018,7 @@ var gViewController = {
         return aAddon && aAddon.isDebuggable && debuggerEnabled && remoteEnabled;
       }
     },
+#endif
 
     cmd_showItemPreferences: {
       isEnabled: function cmd_showItemPreferences_isEnabled(aAddon) {
diff --git a/toolkit/mozapps/extensions/content/extensions.xml b/toolkit/mozapps/extensions/content/extensions.xml
index 7fe17be2ab..cbd05bfa95 100644
--- a/toolkit/mozapps/extensions/content/extensions.xml
+++ b/toolkit/mozapps/extensions/content/extensions.xml
@@ -1628,11 +1628,13 @@
         ]]></body>
       </method>
 
+#ifdef MOZ_DEVTOOLS
       <method name="debug">
         <body><![CDATA[
           gViewController.doCommand("cmd_debugItem", this.mAddon);
         ]]></body>
       </method>
+#endif
 
       <method name="showPreferences">
         <body><![CDATA[
diff --git a/toolkit/mozapps/extensions/content/extensions.xul b/toolkit/mozapps/extensions/content/extensions.xul
index c1a8edc86b..c5eeb534ff 100644
--- a/toolkit/mozapps/extensions/content/extensions.xul
+++ b/toolkit/mozapps/extensions/content/extensions.xul
@@ -53,8 +53,10 @@
       <menuitem id="menuitem_uninstallItem" command="cmd_uninstallItem"
                 label="&cmd.uninstallAddon.label;"
                 accesskey="&cmd.uninstallAddon.accesskey;"/>
+#ifdef MOZ_DEVTOOLS
       <menuitem id="menuitem_debugItem" command="cmd_debugItem"
                 label="&cmd.debugAddon.label;"/>
+#endif
       <menuseparator id="addonitem-menuseparator" />
       <menuitem id="menuitem_preferences" command="cmd_showItemPreferences"
 #ifdef XP_WIN
@@ -101,7 +103,9 @@
     <command id="cmd_findItemUpdates"/>
     <command id="cmd_showItemPreferences"/>
     <command id="cmd_showItemAbout"/>
+#ifdef MOZ_DEVTOOLS
     <command id="cmd_debugItem"/>
+#endif
     <command id="cmd_enableItem"/>
     <command id="cmd_disableItem"/>
     <command id="cmd_installItem"/>
@@ -631,9 +635,11 @@
 #endif
                             command="cmd_showItemPreferences"/>
                     <spacer flex="1"/>
+#ifdef MOZ_DEVTOOLS
                     <button id="detail-debug-btn" class="addon-control debug"
                             label="Debug"
                             command="cmd_debugItem" />
+#endif
                     <button id="detail-enable-btn" class="addon-control enable"
                             label="&cmd.enableAddon.label;"
                             accesskey="&cmd.enableAddon.accesskey;"
diff --git a/toolkit/mozapps/extensions/internal/XPIProvider.jsm b/toolkit/mozapps/extensions/internal/XPIProvider.jsm
index e1883fb6a8..f7be32ad41 100644
--- a/toolkit/mozapps/extensions/internal/XPIProvider.jsm
+++ b/toolkit/mozapps/extensions/internal/XPIProvider.jsm
@@ -36,8 +36,10 @@ XPCOMUtils.defineLazyModuleGetter(this, "Task",
                                   "resource://gre/modules/Task.jsm");
 XPCOMUtils.defineLazyModuleGetter(this, "OS",
                                   "resource://gre/modules/osfile.jsm");
+#ifdef MOZ_DEVTOOLS
 XPCOMUtils.defineLazyModuleGetter(this, "BrowserToolboxProcess",
                                   "resource://devtools/client/framework/ToolboxProcess.jsm");
+#endif
 XPCOMUtils.defineLazyModuleGetter(this, "ConsoleAPI",
                                   "resource://gre/modules/Console.jsm");
 
@@ -138,7 +140,9 @@ const FIREFOX_APPCOMPATVERSION        = "56.9"
 
 // The value for this is in Makefile.in
 #expand const DB_SCHEMA                       = __MOZ_EXTENSIONS_DB_SCHEMA__;
+#ifdef MOZ_DEVTOOLS
 const NOTIFICATION_TOOLBOXPROCESS_LOADED      = "ToolboxProcessLoaded";
+#endif
 
 // Properties that exist in the install manifest
 const PROP_METADATA      = ["id", "version", "type", "internalName", "updateURL",
@@ -1846,8 +1850,10 @@ this.XPIProvider = {
   _enabledExperiments: null,
   // A Map from an add-on install to its ID
   _addonFileMap: new Map(),
+#ifdef MOZ_DEVTOOLS
   // Flag to know if ToolboxProcess.jsm has already been loaded by someone or not
   _toolboxProcessLoaded: false,
+#endif
   // Have we started shutting down bootstrap add-ons?
   _closing: false,
 
@@ -2083,6 +2089,8 @@ this.XPIProvider = {
       Services.prefs.addObserver(PREF_EM_MIN_COMPAT_APP_VERSION, this, false);
       Services.prefs.addObserver(PREF_EM_MIN_COMPAT_PLATFORM_VERSION, this, false);
       Services.obs.addObserver(this, NOTIFICATION_FLUSH_PERMISSIONS, false);
+
+#ifdef MOZ_DEVTOOLS
       if (Cu.isModuleLoaded("resource://devtools/client/framework/ToolboxProcess.jsm")) {
         // If BrowserToolboxProcess is already loaded, set the boolean to true
         // and do whatever is needed
@@ -2094,6 +2102,7 @@ this.XPIProvider = {
         // Else, wait for it to load
         Services.obs.addObserver(this, NOTIFICATION_TOOLBOXPROCESS_LOADED, false);
       }
+#endif
 
       let flushCaches = this.checkForChanges(aAppChanged, aOldAppVersion,
                                              aOldPlatformVersion);
@@ -4088,12 +4097,14 @@ this.XPIProvider = {
       }
       return;
     }
+#ifdef MOZ_DEVTOOLS
     else if (aTopic == NOTIFICATION_TOOLBOXPROCESS_LOADED) {
       Services.obs.removeObserver(this, NOTIFICATION_TOOLBOXPROCESS_LOADED, false);
       this._toolboxProcessLoaded = true;
       BrowserToolboxProcess.on("connectionchange",
                                this.onDebugConnectionChange.bind(this));
     }
+#endif
 
     if (aTopic == "nsPref:changed") {
       switch (aData) {
@@ -4358,12 +4369,14 @@ this.XPIProvider = {
       logger.warn("Error loading bootstrap.js for " + aId, e);
     }
 
+#ifdef MOZ_DEVTOOLS
     // Only access BrowserToolboxProcess if ToolboxProcess.jsm has been
     // initialized as otherwise, when it will be initialized, all addons'
     // globals will be added anyways
     if (this._toolboxProcessLoaded) {
       BrowserToolboxProcess.setAddonOptions(aId, { global: this.bootstrapScopes[aId] });
     }
+#endif
   },
 
   /**
@@ -4383,11 +4396,13 @@ this.XPIProvider = {
     this.persistBootstrappedAddons();
     this.addAddonsToCrashReporter();
 
+#ifdef MOZ_DEVTOOLS
     // Only access BrowserToolboxProcess if ToolboxProcess.jsm has been
     // initialized as otherwise, there won't be any addon globals added to it
     if (this._toolboxProcessLoaded) {
       BrowserToolboxProcess.setAddonOptions(aId, { global: null });
     }
+#endif
   },
 
   /**
