diff --git a/dom/workers/RuntimeService.cpp b/dom/workers/RuntimeService.cpp
index 8d9de1e01a..5f5485dba2 100644
--- a/dom/workers/RuntimeService.cpp
+++ b/dom/workers/RuntimeService.cpp
@@ -301,6 +301,11 @@ LoadContextOptions(const char* aPrefName, void* /* aClosure */)
   useIon = false;
 #endif
 
+  bool useNativeRegExp = GetWorkerPref<bool>(NS_LITERAL_CSTRING("native_regexp"));
+#if defined(JS_CODEGEN_LOONGARCH64)
+  useNativeRegExp = false;
+#endif
+
   JS::ContextOptions contextOptions;
   contextOptions.setAsmJS(useAsmJS)
                 .setWasm(useWasm)
@@ -308,7 +313,7 @@ LoadContextOptions(const char* aPrefName, void* /* aClosure */)
                       NS_LITERAL_CSTRING("throw_on_asmjs_validation_failure")))
                 .setBaseline(GetWorkerPref<bool>(NS_LITERAL_CSTRING("baselinejit")))
                 .setIon(useIon)
-                .setNativeRegExp(GetWorkerPref<bool>(NS_LITERAL_CSTRING("native_regexp")))
+                .setNativeRegExp(useNativeRegExp)
                 .setAsyncStack(GetWorkerPref<bool>(NS_LITERAL_CSTRING("asyncstack")))
                 .setWerror(GetWorkerPref<bool>(NS_LITERAL_CSTRING("werror")))
                 .setStreams(GetWorkerPref<bool>(NS_LITERAL_CSTRING("streams")))
diff --git a/js/src/irregexp/RegExpEngine.cpp b/js/src/irregexp/RegExpEngine.cpp
index 75c6f4547a..058f3ba354 100644
--- a/js/src/irregexp/RegExpEngine.cpp
+++ b/js/src/irregexp/RegExpEngine.cpp
@@ -1251,7 +1251,7 @@ SampleChars(FrequencyCollator* collator, const CharT* chars, size_t length)
 static bool
 IsNativeRegExpEnabled(JSContext* cx)
 {
-#ifdef JS_CODEGEN_NONE
+#if defined(JS_CODEGEN_NONE) || defined(JS_CODEGEN_LOONGARCH64)
     return false;
 #else
     return cx->options().nativeRegExp();
diff --git a/js/xpconnect/src/XPCJSContext.cpp b/js/xpconnect/src/XPCJSContext.cpp
index 1a102fe820..da8d6b137c 100644
--- a/js/xpconnect/src/XPCJSContext.cpp
+++ b/js/xpconnect/src/XPCJSContext.cpp
@@ -1426,6 +1426,7 @@ ReloadPrefsCallback(const char* pref, void* data)
     useAsmJS = false;
     useWasm = false;
     useWasmBaseline = false;
+    useNativeRegExp = false;
 #endif
 
     bool parallelParsing = Preferences::GetBool(JS_OPTIONS_DOT_STR "parallel_parsing");
diff --git a/modules/libpref/init/all.js b/modules/libpref/init/all.js
index cbf3478dc1..4b240a65b0 100644
--- a/modules/libpref/init/all.js
+++ b/modules/libpref/init/all.js
@@ -1289,7 +1289,11 @@ pref("javascript.options.wasm_baselinejit", true);
 #else
 pref("javascript.options.wasm_baselinejit", false);
 #endif
+#ifdef JS_CODEGEN_LOONGARCH64
+pref("javascript.options.native_regexp",    false);
+#else
 pref("javascript.options.native_regexp",    true);
+#endif
 pref("javascript.options.parallel_parsing", true);
 // asyncstack is used for debugging promises in devtools.
 pref("javascript.options.asyncstack",       false);